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KMID : 0370220150590040184
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Yakhak Hoeji
2015 Volume.59 No. 4 p.184 ~ p.189
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Serotonin as a Possible Modulator of Impulsive Behavior in Wistar Rats
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Kim Chong-Ah
Cheong Jae-Hoon
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Abstract
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We compared impulsive behaviors in Wistar rats and in Wistar-Kyoto rats. There was no significant difference in locomotor activity between them. However, Wistar rats showed high activity in 5-choice serial reaction time track. When Wistar rats were treated with atomoxetin (3 mg/kg), methylphenidate (2 mg/kg) or amphetamine (2 mg/kg), they showed less impulsive behavior. Serotonin contents in prefrontal cortex and brain stem also increased. In conclusion, we suggest that Wistar rats could be used as animal model for impulsive behavior analysis. In addition, serotonin might be related with this impulsivity.
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KEYWORD
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Wistar rat, WKY, impulsivity, locomotor activity, serotonin
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